Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers

This research paper demonstrates a novel approach to targeting intracellular oncoproteins using dimeric IgA (dIgA) antibodies that can enter cancer cells via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR). dIgA antibodies, but not IgG antibodies, can enter into cancer cells that express pIgR through receptor-mediated transcytosis. This occurs in various epithelial cancer cells lines including ovarian, lung and colon. The dIgA antibodies can specifically bind to intracellular oncoproteins such as mutant KRAS (G12D) and IDH1 (R132H). Binding redirects the proteins from recycling endosomes to early/late endosomes through which the dIgA-oncoprotein complex traffics and gets expelled from the cell. <a href="https://medium.com/@axialxyz/targeting-intracellular-oncoproteins-with-dimeric-iga-promotes-expulsion-from-the-cytoplasm-and-ad3ce326caea">Website</a>