Tag: Targeting

Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers

This research paper demonstrates a novel approach to targeting intracellular oncoproteins using dimeric IgA (dIgA) antibodies that can enter cancer cells via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR). dIgA antibodies, but not IgG antibodies, can enter into cancer cells th...