ProSTAGE: Predicting Effects of Mutations on Protein Stability by Using Protein Embeddings and Graph Convolutional Networks. Article review

The thermodynamic stability of proteins has a major impact on their structure, function, expression, and solubility. Mutations can reduce the thermodynamic stability of proteins and lead to various diseases, such as genetic disorders, cancer, and neurodegenerative diseases. For the development of biotechnology products such as protein drugs and biocatalysts, it is important to determine the effect of mutations on the thermodynamic stability of a protein. Experimental measurements are desirable, but they may be impractical for a detailed study of a protein. Therefore, the development of computational methods is an important step for the design of customized proteins in biotechnology, personalized medicine, and precision diagnostics. <a href="https://medium.com/@mykyta.prud/prostage-predicting-effects-of-mutations-on-protein-stability-by-using-protein-embeddings-and-f3394a87a05e">Learn More</a>