Neurogenesis with AMPAkines.
<p>Ampakines, also known as AMPAkines, form a subgroup of positive allosteric modulators targeting AMPA receptors. Characterized by a benzamide or closely related chemical structure, these compounds, often referred to as "CX compounds," interact with and enhance the function of AMPA receptors. While all ampakines act as positive allosteric modulators (PAMs) of AMPA receptors, it's important to note that not all AMPA receptor PAMs fall under the category of ampakines.</p>
<p>An example of an early and prototypical ampakine is CX-516. The therapeutic potential of ampakines is currently under investigation for conditions involving cognitive impairment, such as Alzheimer's disease, Parkinson's disease, schizophrenia, treatment-resistant depression (TRD), and neurological disorders like attention deficit hyperactivity disorder (ADHD).</p>
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