How do psychedelics affect the brain?

In recent years there has been a renaissance of research into the use of psychedelics for the treatment of a wide array of psychopathologies. Mental health concerns as various as mood disorders, anxiety disorders, body-image disorders, addiction, and others have all been shown to be amenable to psychedelic therapy [1]. In many cases, results suggest that one or two sessions of psychedelic assisted psychotherapy can lead to lasting reduction in symptoms, even when other mainline therapies have failed. Indeed, a recent high quality double-blind study has shown the classic psychedelic drug psilocybin to be as effective at reducing symptoms of major depressive disorder as SSRIs [2]. These promising results have led to an increase of interest from academic, commercial, and legal entities. With all of this interest, it is increasingly likely that psilocybin will become a legal and available treatment option for individuals with depression and potentially other related issues in the coming years.

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