New ALS link: stem cell motor neurons undergo ferroptosis

Wan did his postdoctoral training in my lab some years, so I know him well. In his new paper, he reports that mouse motor neurons generated in the laboratory are sensitive to ferroptosis, a form of iron-dependent cell death that we discovered and named in my lab a decade ago. <img alt="" src="https://miro.medium.com/v2/resize:fit:700/1*HBijvXS_SmLOieaLi_72Jw.jpeg" style="height:467px; width:700px" /> Image of motor neuron (licensed from Adobe Stock) Wan and his team used a mouse embryonic stem cell line (named iNIL) to generate motor neurons in the laboratory, using established methods, and then tested whether these motor neurons were sensitive to ferroptosis, which has been previously linked to a variety of neurodegenerative diseases. <a href="https://brentstockwell.medium.com/mouse-motor-neurons-derived-from-embryonic-stem-cells-undergo-ferroptosis-a-link-to-als-82969cebc490">Website</a>