Tag: Ligands

An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4

This paper presents a new methionine-directed activity-based protein profiling (ABPP) platform to identify and target functional methionine sites on proteins for covalent ligand discovery. Using Redox-Activated Chemical Tagging (ReACT) probes that target methionine residues, the authors identifie...