Beyond the Somatic Mutation Theory of Cancer
<p><strong>“The problem lies not so much in developing new ideas, but in escaping from old ones</strong>” John Maynard Keynes</p>
<p>By 2009, it was clear that the somatic mutation theory (SMT) — that cancer was simply a random collection of genetic mutations — was leading exactly nowhere. Billions of research dollars and decades of work yielded virtually no useful treatments. So, in an uncharacteristically open-minded and insightful move, the government decided to do something <a href="https://www.aps.org/publications/apsnews/201003/nih.cfm" rel="noopener ugc nofollow" target="_blank">very smart. It asked for help</a>. But where to get that help? The National Cancer Institute (NCI) was already giving millions of research dollars to cancer biologists, cancer researchers, geneticists, physiologists, doctors etc. No, in a rare moment of clarity, the NCI decided that in order to think ‘outside the box’ you needed people who professionally <em>live</em> outside cancer’s box. Cancer researchers and doctors were so far in the box, they couldn’t see outside.</p>
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