Henry VIII inherited his first wife, Catherine of Aragon, when his older brother died. She didn’t produce a son, he fell for Anne Boleyn, so he divorced her.
Anne got on his nerves fast. She also only produced a daughter, and he had her executed for spurious reasons to marry Jane Seymour.
Jane was allegedly his great love. But, she died in childbirth, so he didn’t have time to go off her.