Tag: Regeneration

To Create a Regenerative Future, We Must Find the First Principles of Regeneration

Imagine you have been feeling a bit sluggish and tired lately. You go to the doctor and get your blood tested. Three days later, she gets back to you with the results: you have a phosphorus deficiency. She prescribes phosphorus supplements and advices you to take them daily. But you are curiou...

Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration

The enzyme interleukin-4 induced 1 (IL4I1) is expressed in myeloid cells during remyelination in mouse models of multiple sclerosis (MS). Knocking out IL4I1 in myeloid cells leads to impaired remyelination efficiency. IL4I1 converts aromatic amino acids into alpha-keto acids (AKAs) like phenylpyr...