Natural Product Synthesis in the 21st Century: Beyond the Mountain Top
<p>The review provides a broad perspective on natural product total synthesis and where the field may be headed in the future by Professor Ryan Shenvi. The introductory sections establish some key concepts and terminology around chemical synthesis and natural products. Chemical synthesis joins molecules together through chemical reactions, while degradation breaks them apart. Biosynthesis occurs within cells, self-assembly relies on weak interactions. Shenvi defines natural products as small molecule secondary metabolites produced by organisms, often as “chemical weapons” to impact other organisms. Their properties are refined by natural selection to allow absorption, distribution, and target binding in living systems.</p>
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