Which Solvent is Better for Chromatography: Methanol or Acetonitrile?
<p>Acetonitrile and methanol are both used as solvents in liquid chromatography (LC) or high-performance LC (HPLC) systems. Even though they share many characteristics, <em>acetonitrile is generally preferred as a solvent over methanol because it tends to give a better signal from an evaporative light scattering detector (ELSD)</em>.</p>
<p>If ultra-high pressure liquid chromatography is used with tandem mass spectrometry (UHPLC/MS), acetonitrile is preferred; this is due to the fact that it forms less stable adducts compared to methanol. In addition, acetonitrile has a higher dielectric constant than methanol. This can increase the rate of migration of solutes in an electric field.</p>
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