Of Yeast and Men: Longevity and Sirtuins

Sirtuins are a family of signaling proteins. They are named after their first documented member, Sir2. SIR is an acronym for “Silent Information Regulator.” SIR genes were found to suppress transcription silencing through a genetic screen for mutations (Dang, 2014). Their silencing function is essential to regulating gene expression, influencing longevity, metabolism, and responses to cellular stress (Wu, 2022). Although sirtuins were discovered in 1979, it took twenty years for widespread interest to ignite. This was because two studies linked Sir2 activity withextended replicative lifespan in yeast (Sinclair and Guarente, 1997; Guarente, 2000). <a href="https://bioviva-science.medium.com/of-yeast-and-men-longevity-and-sirtuins-32a10a8a23a5">Website</a>