Future of Covid: Will Schizophrenia Haunt the Next Generation?
<p>Whenever I watch horror ghost movies, I always think the characters may have <a href="https://www.nhsinform.scot/illnesses-and-conditions/mental-health/schizophrenia" rel="noopener ugc nofollow" target="_blank">schizophrenia</a>. If Covid-19 had occurred a generation or two earlier, I might have thought that the schizophrenia character‘s mother caught Covid during pregnancy.</p>
<p>This idea struck me when a commenter on my <a href="https://medium.com/microbial-instincts/immunity-debt-vs-theft-what-explains-the-post-lockdown-infection-rebounds-2a218283936e?sk=0dac5b838d199b8b524d82f214dd214d" rel="noopener">previous article</a> shared a new study, showing that schizophrenia-specific genes upregulated in pregnant mothers with Covid-19 vs. no Covid. <a href="https://www.nature.com/articles/s41467-023-38140-1" rel="noopener ugc nofollow" target="_blank">This study</a> isn’t to be taken lightly. It was published in a prestigious journal, <em>Nature Communications</em>, led by world-renowned scientists in the schizophrenia research field.</p>
<h1>A backdrop on schizophrenia</h1>
<p>A patient affected with schizophrenia can’t differentiate between imagined thoughts from reality. As a result, they may <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678179/" rel="noopener ugc nofollow" target="_blank">believe in</a> supernatural beings like ghosts. Schizophrenia is a mental disorder with symptoms of delusions, hallucinations, and other behavioral anomalies.</p>
<p>Schizophrenia typically occurs earlier in men (late adolescence to early twenties) than in women (late twenties). <a href="https://www.who.int/news-room/fact-sheets/detail/schizophrenia#" rel="noopener ugc nofollow" target="_blank">About</a> <a href="https://academic.oup.com/epirev/article/30/1/67/621138?login=false" rel="noopener ugc nofollow" target="_blank">0.3–0.7%</a> of the adult population has schizophrenia. Its <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745031/" rel="noopener ugc nofollow" target="_blank">risk</a> <a href="https://academic.oup.com/bmb/article/73-74/1/1/332342" rel="noopener ugc nofollow" target="_blank">factors</a> include being male, pregnancy/birth complications, high parental age, early traumatic life events, and social isolation.</p>
<p>But none of these factors fully explain or are specific to schizophrenia. Birth complications and early traumatic life events are also risk factors for <a href="https://www.sciencedirect.com/science/article/pii/S0165178105000508?via%3Dihub=" rel="noopener ugc nofollow" target="_blank">borderline personality</a> or <a href="https://link.springer.com/article/10.1007/s00406-004-0521-2" rel="noopener ugc nofollow" target="_blank">anxiety</a> disorders, for instance</p>
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