Exploring MAOIs for Depression
<p>I’m considering trying an MAOI (monoamine oxidase inhibitor) instead of my current SNRI (serotonin-norepinephrine reuptake inhibitor) for treating <a href="https://8enmann.medium.com/my-depression-and-the-magic-of-ssris-68f49967da74" rel="noopener">depression</a>. While there are some potential risks, like interactions with tyramine in foods leading to acute hypertension, it seems these may be overblown according to <a href="https://pubmed.ncbi.nlm.nih.gov/30255284/" rel="noopener ugc nofollow" target="_blank">this paper</a> (though it doesn’t look very reputable and needs further investigation).</p>
<p>Notably, Scott Alexander of Slate Star Codex <a href="https://slatestarcodex.com/2015/04/30/prescriptions-paradoxes-and-perversities/" rel="noopener ugc nofollow" target="_blank">loves MAOIs</a>. He argues they can be very effective even for treatment-resistant depression.</p>
<p>The paper discusses how tyramine response can be measured relatively safely:</p>
<p><a href="https://8enmann.medium.com/exploring-maois-for-depression-8013ec7b26e7"><strong>Read More</strong></a></p>
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