I’m considering trying an MAOI (monoamine oxidase inhibitor) instead of my current SNRI (serotonin-norepinephrine reuptake inhibitor) for treating depression. While there are some potential risks, like interactions with tyramine in foods leading to acute hypertension, it seems these may be overblown according to this paper (though it doesn’t look very reputable and needs further investigation).
Notably, Scott Alexander of Slate Star Codex loves MAOIs. He argues they can be very effective even for treatment-resistant depression.
The paper discusses how tyramine response can be measured relatively safely: